Publications

Abstract (Expand)

Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a ...

Authors: Nils Meyer, J. Rettner, Markus Werner, Oliver Werz, Georg Pohnert

Date Published: No date defined

Journal: Mar Drugs

Abstract (Expand)

Marine and lake snow is a continuous shower of mixed organic and inorganic aggregates falling from the upper water where primary production is substantial. These pelagic aggregates provide a niche for ...

Authors: J. F. Mori, N. Ueberschaar, S. Lu, R. E. Cooper, G. Pohnert, K. Kusel

Date Published: No date defined

Journal: ISME J

Abstract (Expand)

Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close ...

Authors: J. Linde, S. Duggan, M. Weber, F. Horn, P. Sieber, D. Hellwig, K. Riege, M. Marz, R. Martin, Reinhard Guthke, O. Kurzai

Date Published: No date defined

Journal: Nucleic Acids Res

Abstract (Expand)

Polyketide synthases (PKSs) occur in many bacteria, fungi and plants. They are highly versatile enzymes involved in the biosynthesis of a large variety of compounds including antimicrobial agents, ...

Authors: N. Heimerl, E. Hommel, M. Westermann, D. Meichsner, M. Lohr, Christian Hertweck, A. R. Grossman, Maria Mittag, Sasso Severin

Date Published: No date defined

Journal: Plant J

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The recognition of quinolinic carboxylic acids as natural chelants and the recent observation of a high production of 8-hydroxyquinoline-2-carboxylic acid (8-HQA) in the gut of several Noctuid larvae ...

Authors: Sofia Gama, Mariachiara Frontauria, Nico Ueberschaar, Giuseppe Brancato, Demetrio Milea, Silvio Sammartano, Winfried Plass

Date Published: 9th Apr 2018

Journal: Royal Society of Chemistry (RSC)

Abstract (Expand)

A benzoin-derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker ...

Authors: Christoph Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, Michael Pröhl, M. Hentschel, M. Hartlieb, A. Traeger, Georg Pohnert, S. Schubert, Michael Gottschaldt, Ulrich S. Schubert

Date Published: No date defined

Journal: Angew Chem Int Ed Engl

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Investigating microbial interactions from an ecological perspective is a particularly fruitful approach to unveil both new chemistry and bioactivity. Microbial predator-prey interactions in particular ...

Authors: J. Arp, S. Gotze, R. Mukherji, D. J. Mattern, M. Garcia-Altares, M. Klapper, D. A. Brock, Axel A. Brakhage, J. E. Strassmann, D. C. Queller, B. Bardl, K. Willing, G. Peschel, P. Stallforth

Date Published: No date defined

Journal: Proc Natl Acad Sci U S A

Abstract (Expand)

The marine macroalga Ulva mutabilis (Chlorophyta) develops into callus-like colonies consisting of undifferentiated cells and abnormal cell walls under axenic conditions. Ulva mutabilis is routinely ...

Authors: R. W. Kessler, A. Weiss, Stefan Kügler, C. Hermes, Thomas Wichard

Date Published: No date defined

Journal: Mol Ecol

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Introduction: Stable isotopic labeling experiments are powerful tools to study metabolic pathways, to follow tracers and fluxes in biotic and abiotic transformations and to elucidate molecules involved ...

Authors: Tim U. H. Baumeister, Nico Ueberschaar, Wolfgang Schmidt-Heck, Jan-Frieder Mohr, Michael Deicke, Thomas Wichard, Reinhard Guthke, Georg Pohnert

Date Published: 27th Feb 2018

Journal: Springer Nature

Abstract (Expand)

Piriformospora indica, an endophytic root-colonizing fungus, efficiently promotes plant growth and induces resistance to abiotic stress and biotic diseases. The fungal cell wall extract induces cytoplasmic ...

Authors: J. M. Johnson, Johannes Thürich, E. K. Petutschnig, L. Altschmied, D. Meichsner, I. Sherameti, J. Dindas, A. Mrozinska, C. Paetz, Sandra Scholz, A. C. Furch, V. Lipka, R. Hedrich, B. Schneider, A. Svatos, Ralf Oelmüller

Date Published: No date defined

Journal: Plant Physiol

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Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes ...

Authors: Oliver Werz, J. Gerstmeier, S. Libreros, X. De la Rosa, Markus Werner, P. C. Norris, N. Chiang, C. N. Serhan

Date Published: No date defined

Journal: Nat Commun

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Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication signals during coexistence with other microorganisms, ...

Authors: J. Macheleidt, D. J. Mattern, Juliane Fischer, Tina Netzker, J. Weber, Volker Schroeckh, V. Valiante, Axel A. Brakhage

Date Published: 13th Oct 2016

Journal: Annu Rev Genet

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Endogenous jasmonates are important regulators of plant defenses. If and how they enable plants to maintain their reproductive output when facing community-level herbivory under natural conditions, ...

Authors: R. A. Machado, M. McClure, M. R. Herve, Ian T. Baldwin, M. Erb

Date Published: 30th Jun 2016

Journal: Elife

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Cysteinyl leukotrienes (cys-LTs) cause bronchoconstriction in anaphylaxis and asthma. They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) ...

Authors: S. Liening, G. K. Scriba, S. Rummler, C. Weinigel, T. K. Kleinschmidt, J. Z. Haeggstrom, Oliver Werz, U. Garscha

Date Published: 2nd Aug 2016

Journal: Biochim Biophys Acta

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Secondary metabolite diversity is considered an important fitness determinant for plants' biotic and abiotic interactions in nature. This diversity can be examined in two dimensions. The first one ...

Authors: Dapeng Li, S. Heiling, Ian T. Baldwin, E. Gaquerel

Date Published: 9th Nov 2016

Journal: Proc Natl Acad Sci U S A

Abstract (Expand)

S-adenosyl-l-methionine (SAM)-dependent methyltransfer is a common biosynthetic strategy to modify natural products. We investigated the previously uncharacterized Aspergillus fumigatus methyltransferase ...

Authors: D. Kalb, T. Heinekamp, S. Schieferdecker, Markus Nett, Axel A. Brakhage, Dirk Hoffmeister

Date Published: 22nd Jul 2016

Journal: Chembiochem

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Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria ...

Authors: H. Guo, Nina Kreuzenbeck, S. Otani, M. Garcia-Altares, H. M. Dahse, C. Weigel, D. K. Aanen, Christian Hertweck, M. Poulsen, Christine Beemelmanns

Date Published: 25th Jun 2016

Journal: Org Lett

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Commercially-available linear and branched PEIs (LPEI and BPEI) were chemically-modified with carbohydrates and carbohydrate-mimetics to improve biocompatibility. Hydroxyl moieties were installed in a ...

Authors: Christoph Englert, Mareva Fevre, Rudy J. Wojtecki, Wei Cheng, Qingxing Xu, Chuan Yang, Xiyu Ke, Matthias Hartlieb, Kristian Kempe, Jeannette M. García, Robert J. Ono, Ulrich S. Schubert, Yi Yan Yang, James L. Hedrick

Date Published: No date defined

Journal: Royal Society of Chemistry (RSC)

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BACKGROUND: Plant-mediated RNAi (PMRi) silencing of insect genes has enormous potential for crop protection, but whether it works robustly under field conditions, particularly with lepidopteran pests, ...

Authors: S. Poreddy, J. Li, Ian T. Baldwin

Date Published: 15th Nov 2017

Journal: BMC Plant Biol

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When herbivores attack, plants specifically reconfigure their metabolism. Herbivory on the wild tobacco Nicotiana attenuata strongly induces the R2R3 MYB transcriptional activator MYB8, which was ...

Authors: Martin Schäfer, C. Brutting, S. Xu, Z. Ling, A. Steppuhn, Ian T. Baldwin, Meredith Schuman

Date Published: 27th Aug 2017

Journal: J Integr Plant Biol

Abstract:

Not specified

Author: Christian Hertweck

Date Published: No date defined

Journal: Elsevier BV

Abstract (Expand)

In both freshwater and marine ecosystems, phytoplankton are the most dominant primary producers, contributing substantially to aquatic food webs. Algicidal bacteria that can associate to microalgae ...

Authors: Nils Meyer, Arite Bigalke, A. Kaulfuss, Georg Pohnert

Date Published: 30th Sep 2017

Journal: FEMS Microbiol Rev

Abstract (Expand)

Microbial communities in soil, groundwater, and rock of two sites in limestone were investigated to determine community parameters differentiating habitats in two lithostratigraphic untis. Lower ...

Authors: A. Meier, M. K. Singh, A. Kastner, D. Merten, G. Buchel, Erika Kothe

Date Published: 7th Jul 2017

Journal: J Basic Microbiol

Abstract (Expand)

Biomineralization of (magnesium) calcite and vaterite by bacterial isolates has been known for quite some time. However, the extracellular precipitation has hardly ever been linked to different ...

Authors: Aileen Meier, Anne Kastner, Dennis Harries, Maria Wierzbicka-Wieczorek, Juraj Majzlan, Georg Büchel, Erika Kothe

Date Published: 6th Nov 2017

Journal: Copernicus GmbH

Abstract (Expand)

In higher plants, jasmonates are lipid-derived signaling molecules that control many physiological processes, including responses to abiotic stress, defenses against insects and pathogens, and development. ...

Authors: Guillermo Hugo Jiménez-Alemán, S. Secinti, Wilhelm Boland

Date Published: 1st Jul 2017

Journal: Z Naturforsch C

Abstract (Expand)

Root colonization by endophytic fungus Piriformospora indica facilitating growth/development and stress tolerance has been demonstrated in various host plants. However, global metabolomic studies are ...

Authors: Mo Da-Sang Hua, Rajendran Senthil Kumar, Lie-Fen Shyur, Yuan-Bin Cheng, Zhihong Tian, Ralf Oelmüller, Kai-Wun Yeh

Date Published: 24th Aug 2017

Journal: Springer Nature

Abstract (Expand)

Terrestrial symbiotic cyanobacteria of the genus Nostoc exhibit a large potential for the production of bioactive natural products of the nonribosomal peptide, polyketide and ribosomal peptide classes, ...

Authors: A. Guljamow, M. Kreische, K. Ishida, A. Liaimer, B. Altermark, L. Bahr, Christian Hertweck, R. Ehwald, E. Dittmann

Date Published: 25th Sep 2017

Journal: Appl Environ Microbiol

Abstract (Expand)

The guts of insects harbor symbiotic bacterial communities. However, due to their complexity, it is challenging to relate a specific symbiotic phylotype to its corresponding function. In the present ...

Authors: P. Alonso-Pernas, S. Bartram, E. M. Arias-Cordero, A. L. Novoselov, L. Halty-deLeon, Y. Shao, Wilhelm Boland

Date Published: 28th Oct 2017

Journal: Front Microbiol

Abstract (Expand)

Pharmacological interference with vacuolar-type H(+)-ATPase (V-ATPase), a proton-translocating enzyme involved in protein transport and pH regulation of cell organelles, is considered a potential ...

Authors: L. Thomas, Z. Rao, J. Gerstmeier, M. Raasch, C. Weinigel, S. Rummler, D. Menche, R. Muller, C. Pergola, A. Mosig, Oliver Werz

Date Published: 13th Feb 2017

Journal: Biochem Pharmacol

Abstract (Expand)

Transcription factors (TFs) are essential regulators of gene expression in a cell; the entire repertoire of TFs (TFome) of a species reflects its regulatory potential and the evolutionary history of ...

Author: Ekaterina Shelest

Date Published: 20th May 2017

Journal: Front Genet

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The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) ...

Authors: Simona Pace, A. Rossi, V. Krauth, F. Dehm, F. Troisi, R. Bilancia, C. Weinigel, S. Rummler, Oliver Werz, L. Sautebin

Date Published: 21st Jun 2017

Journal: Sci Rep

Abstract (Expand)

Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). LT biosynthesis inhibitors are currently under clinical investigation as treatments for ...

Authors: Simona Pace, C. Pergola, F. Dehm, A. Rossi, J. Gerstmeier, F. Troisi, H. Pein, A. M. Schaible, C. Weinigel, S. Rummler, H. Northoff, S. Laufer, T. J. Maier, O. Radmark, B. Samuelsson, Andreas Koeberle, L. Sautebin, Oliver Werz

Date Published: 25th Jul 2017

Journal: J Clin Invest

Abstract (Expand)

Raman spectroscopy is currently advertised as a hot and ambitious technology that has all of the features needed to characterize and identify bacteria. Raman spectroscopy is rapid, easy to use, ...

Authors: B. Lorenz, C. Wichmann, S. Stockel, Petra Rösch, Jürgen Popp

Date Published: 12th Feb 2017

Journal: Trends Microbiol

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The green marine macroalgae of the class Ulvophyceae (Ulvophytes) are common algae distributed worldwide particularly in intertidal areas, which play a key role in aquatic ecosystems. They are potentially ...

Authors: F. Ghaderiardakani, J. C. Coates, Thomas Wichard

Date Published: 16th Aug 2017

Journal: FEMS Microbiol Ecol

Abstract (Expand)

BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent ...

Authors: R. P. de Vries, R. Riley, A. Wiebenga, G. Aguilar-Osorio, S. Amillis, C. A. Uchima, G. Anderluh, M. Asadollahi, M. Askin, K. Barry, E. Battaglia, O. Bayram, T. Benocci, S. A. Braus-Stromeyer, C. Caldana, D. Canovas, G. C. Cerqueira, F. Chen, W. Chen, C. Choi, A. Clum, R. A. Dos Santos, A. R. Damasio, G. Diallinas, T. Emri, E. Fekete, M. Flipphi, S. Freyberg, A. Gallo, C. Gournas, R. Habgood, M. Hainaut, M. L. Harispe, B. Henrissat, K. S. Hilden, R. Hope, A. Hossain, E. Karabika, L. Karaffa, Z. Karanyi, N. Krasevec, A. Kuo, H. Kusch, K. LaButti, E. L. Lagendijk, A. Lapidus, A. Levasseur, E. Lindquist, A. Lipzen, A. F. Logrieco, A. MacCabe, M. R. Makela, I. Malavazi, P. Melin, V. Meyer, N. Mielnichuk, M. Miskei, A. P. Molnar, G. Mule, C. Y. Ngan, M. Orejas, E. Orosz, J. P. Ouedraogo, K. M. Overkamp, H. S. Park, G. Perrone, F. Piumi, P. J. Punt, A. F. Ram, A. Ramon, S. Rauscher, E. Record, D. M. Riano-Pachon, V. Robert, J. Rohrig, R. Ruller, A. Salamov, N. S. Salih, R. A. Samson, E. Sandor, M. Sanguinetti, T. Schutze, K. Sepcic, Ekaterina Shelest, G. Sherlock, V. Sophianopoulou, F. M. Squina, H. Sun, A. Susca, R. B. Todd, A. Tsang, S. E. Unkles, N. van de Wiele, D. van Rossen-Uffink, J. V. Oliveira, T. C. Vesth, J. Visser, J. H. Yu, M. Zhou, M. R. Andersen, D. B. Archer, S. E. Baker, I. Benoit, Axel A. Brakhage, G. H. Braus, Juliane Fischer, J. C. Frisvad, G. H. Goldman, J. Houbraken, B. Oakley, I. Pocsi, C. Scazzocchio, B. Seiboth, P. A. vanKuyk, J. Wortman, P. S. Dyer, I. V. Grigoriev

Date Published: 16th Feb 2017

Journal: Genome Biol

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The formation of Fe(III) oxides in natural environments occurs in the presence of natural organic matter (OM), resulting in the formation of OM-mineral complexes that form through adsorption or ...

Authors: Rebecca Cooper, Karin Eusterhues, Carl-Eric Wegner, Kai Uwe Totsche, Kirsten Küsel

Date Published: 6th Jul 2017

Journal: Copernicus GmbH

Abstract (Expand)

The antilarval mushroom polyenes 18-methyl-19-oxoicosaoctaenoic acid and 20-methyl-21-oxodocosanonaenoic acid appear in response to injury of the mycelium of the stereaceous mushroom BY1. We identified ...

Authors: P. Brandt, M. Garcia-Altares, Markus Nett, Christian Hertweck, Dirk Hoffmeister

Date Published: 26th Apr 2017

Journal: Angew Chem Int Ed Engl

Abstract (Expand)

Many antibiotics, chemotherapeutics, crop protection agents and food preservatives originate from molecules produced by bacteria, fungi or plants. In recent years, genome mining methodologies have been ...

Authors: K. Blin, T. Wolf, M. G. Chevrette, X. Lu, C. J. Schwalen, S. A. Kautsar, H. G. Suarez Duran, E. L. C. de Los Santos, H. U. Kim, M. Nave, J. S. Dickschat, D. A. Mitchell, Ekaterina Shelest, R. Breitling, E. Takano, S. Y. Lee, T. Weber, M. H. Medema

Date Published: 2nd May 2017

Journal: Nucleic Acids Res

Abstract (Expand)

Piriformospora indica is an endophytic fungus of Sebacinaceae which colonizes the roots of many plant species and confers benefits to the hosts. We demonstrate that approximately 75% of the genes, which ...

Authors: M. Bakshi, I. Sherameti, D. Meichsner, Johannes Thürich, A. Varma, A. K. Johri, K. W. Yeh, Ralf Oelmüller

Date Published: 28th Jul 2017

Journal: Front Microbiol

Abstract (Expand)

Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) was employed to discriminate between cell differentiation processes in macroalgae. One of the key developmental processes ...

Authors: R. W. Kessler, A. C. Crecelius, Ulrich S. Schubert, Thomas Wichard

Date Published: 11th Jun 2017

Journal: Anal Bioanal Chem

Abstract (Expand)

A method for the stable transformation of the green marine macroalga Ulva mutabilis was developed based on vector plasmids integrating into the genome. By combination of the expression signals (promoter, ...

Authors: Wolfgang Oertel, Thomas Wichard, Adelheid Weissgerber

Date Published: 18th Sep 2015

Journal: Wiley-Blackwell

Abstract (Expand)

The roles of organic matter in seawater have often been discussed from the aspect of metal toxicity and bioavailability in seawater. In fact, organic ligands, as part of the organic matter, can work ...

Author: Thomas Wichard

Date Published: 29th Jul 2016

Journal: Frontiers Media SA

Abstract (Expand)

The morphogenesis of the marine green algae Ulva mutabilis depends on bacteria that release diffusible morphogenetic compounds. Axenic U. mutabilis gametes develop into callus-like colonies without ...

Author: Thomas Wichard

Date Published: 2nd Oct 2016

Journal: Springer Nature

Abstract (Expand)

Growth and morphogenesis of the sea lettuce Ulva (Chlorophyta) depends on the combination of regulative morphogenetic compounds released by specific associated bacteria. Axenic Ulva gametes develop ...

Authors: Thomas Wichard, Anne Weiss, R. Costa

Date Published: No date defined

Journal: Walter de Gruyter GmbH

Abstract (Expand)

Polyunsaturated aldehydes (PUAs) are a group of microalgal metabolites that have attracted a lot of attention due to their biological activity. Determination of PUAs has become an important routine ...

Authors: Constanze Kuhlisch, Michael Deicke, Nico Ueberschaar, Thomas Wichard, Georg Pohnert

Date Published: 15th Oct 2016

Journal: Wiley-Blackwell

Abstract (Expand)

Cell structure and microtubule organisation during gametogenesis of the green alga Ulva mutabilis was studied using light microscopy, transmission electron microscopy (TEM) and tubulin immunofluorescence. ...

Authors: Thomas Wichard, Christos Katsaros, Anne Weiss, Ira Llangos

Date Published: 11th Jan 2017

Journal: Walter de Gruyter GmbH

Abstract (Expand)

A fast and reliable detection and identification of microorganisms is crucial in environmental science, for food quality as well as medical diagnosis. In these fields, all types of Raman spectroscopy ...

Authors: Stephan Stöckel, Johanna Kirchhoff, Ute Neugebauer, Petra Rösch, Jürgen Popp

Date Published: 7th Dec 2015

Journal: Wiley-Blackwell

Abstract (Expand)

The high affinity of GLUT5 transporter for d-fructose in breast cancer cells has been discussed intensely. In this contribution, high molar mass linear poly(ethylene imine) (LPEI) is functionalized ...

Authors: Christoph Englert, Michael Pröhl, J. A. Czaplewska, C. Fritzsche, E. Preussger, Ulrich S. Schubert, A. Traeger, Michael Gottschaldt

Date Published: 4th Apr 2017

Journal: Macromol Biosci

Abstract (Expand)

The marine green macroalga Ulva (Chlorophyta) lives in a mutualistic symbiosis with bacteria that influence growth, development, and morphogenesis. We surveyed changes in Ulva's chemosphere, which ...

Authors: T. Alsufyani, A. Weiss, Thomas Wichard

Date Published: 12th Jan 2017

Journal: Mar Drugs

Abstract (Expand)

Herbivore species sharing a host plant often compete. In this study, we show that host plant-mediated interaction between two insect herbivores - a generalist and a specialist - results in a sex ratio ...

Authors: N. Adam, T. Erler, M. Kallenbach, M. Kaltenpoth, G. Kunert, Ian T. Baldwin, Meredith Schuman

Date Published: 20th Nov 2016

Journal: J Integr Plant Biol

Abstract (Expand)

Natural product discovery efforts have focused primarily on microbial biosynthetic gene clusters (BGCs) containing large multimodular polyketide synthases and nonribosomal peptide synthetases; however, ...

Authors: J. A. Baccile, J. E. Spraker, H. H. Le, E. Brandenburger, C. Gomez, J. W. Bok, J. Macheleidt, Axel A. Brakhage, Dirk Hoffmeister, N. P. Keller, F. C. Schroeder

Date Published: 12th Apr 2016

Journal: Nat Chem Biol

Abstract (Expand)

Nicotiana attenuata germinates from long-lived seedbanks in native soils after fires. Although smoke signals have been known to break seed dormancy, whether they also affect seedling establishment and ...

Authors: M. Wang, M. Schoettner, S. Xu, C. Paetz, J. Wilde, Ian T. Baldwin, K. Groten

Date Published: 24th Nov 2016

Journal: New Phytol

Abstract (Expand)

Among the pathways responsible for the development of inflammatory responses, the cyclooxygenase and lipoxygenase pathways are among the most important ones. Two key enzymes, namely, 5-LO and mPGES-1, ...

Authors: A. Svouraki, U. Garscha, E. Kouloura, Simona Pace, C. Pergola, V. Krauth, A. Rossi, L. Sautebin, M. Halabalaki, Oliver Werz, N. Gaboriaud-Kolar, A. L. Skaltsounis

Date Published: 28th Feb 2017

Journal: J Nat Prod

Abstract (Expand)

Insects develop efficient antimicrobial strategies to flourish in a bacterial world. It has long been proposed that native gut microbiota is an important component of host defense; however, the responsible ...

Authors: Y. Shao, B. Chen, C. Sun, K. Ishida, Christian Hertweck, Wilhelm Boland

Date Published: 21st Jan 2017

Journal: Cell Chem Biol

Abstract (Expand)

A total of 48 analogues of the natural product myxochelin A were prepared and evaluated for their inhibitory effects on human 5-lipoxygenase in both cell-free and cell-based assays. Structure-activity ...

Authors: S. Schieferdecker, S. Konig, Simona Pace, Oliver Werz, Markus Nett

Date Published: 23rd Nov 2016

Journal: ChemMedChem

Abstract (Expand)

Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or reprogramming of M2 may represent ...

Authors: C. Pergola, K. Schubert, Simona Pace, J. Ziereisen, F. Nikels, O. Scherer, S. Huttel, S. Zahler, A. M. Vollmar, C. Weinigel, S. Rummler, R. Muller, M. Raasch, A. Mosig, Andreas Koeberle, Oliver Werz

Date Published: 31st Jan 2017

Journal: Sci Rep

Abstract (Expand)

Aiming to explore alternative mechanisms of cellular uptake and cytotoxicity, we have studied a new family of copper(II) complexes (CuL1-CuL4) with bis(thiosemicarbazone) (BTSC) ligands containing ...

Authors: E. Palma, F. Mendes, G. R. Morais, I. Rodrigues, I. C. Santos, M. P. Campello, P. Raposinho, I. Correia, Sofia Gama, D. Belo, V. Alves, A. J. Abrunhosa, I. Santos, A. Paulo

Date Published: 3rd Dec 2016

Journal: J Inorg Biochem

Abstract (Expand)

Marine and lake snow is a continuous shower of mixed organic and inorganic aggregates falling from the upper water where primary production is substantial. These pelagic aggregates provide a niche for ...

Authors: J. F. Mori, Nico Ueberschaar, S. Lu, Rebecca Cooper, Georg Pohnert, Kirsten Küsel

Date Published: 1st Feb 2017

Journal: ISME J

Abstract (Expand)

Small molecules capable of uncoupling growth-defense in plants are currently not known. In this study, for the first time, semi-synthetic analogues of the phytohormone JA-Ile are employed to uncouple ...

Authors: Guillermo Hugo Jiménez-Alemán, R. A. R. Machado, Ian T. Baldwin, Wilhelm Boland

Date Published: 7th Mar 2017

Journal: Org Biomol Chem

Abstract (Expand)

INTRODUCTION: The picoeukaryotic alga Ostreococcus tauri (Chlorophyta) belongs to the widespread group of marine prasinophytes. Despite its ecological importance, little is known about the metabolism ...

Authors: M. Hirth, S. Liverani, S. Mahlow, F. Y. Bouget, Georg Pohnert, Sasso Severin

Date Published: No date defined

Journal: Metabolomics

Abstract (Expand)

Pathogenic and mutualistic bacteria associated with eukaryotic hosts often lack distinctive genomic features, suggesting regular transitions between these lifestyles. Here we present evidence supporting ...

Authors: L. V. Florez, K. Scherlach, P. Gaube, C. Ross, E. Sitte, C. Hermes, A. Rodrigues, Christian Hertweck, M. Kaltenpoth

Date Published: 30th Apr 2017

Journal: Nat Commun

Abstract (Expand)

Exploring the diversity of plant secondary metabolism requires efficient methods to obtain sufficient structural insights to discriminate previously known from unknown metabolites. De novo structure ...

Authors: S. Heiling, S. Khanal, A. Barsch, G. Zurek, Ian T. Baldwin, E. Gaquerel

Date Published: 11th Jan 2016

Journal: Plant J

Abstract (Expand)

BACKGROUND: Plant metabolites are commonly functionally classified, as defense- or growth-related phytohormones, primary and specialized metabolites, and so forth. Analytical procedures for the ...

Authors: Martin Schäfer, C. Brutting, Ian T. Baldwin, M. Kallenbach

Date Published: 31st May 2016

Journal: Plant Methods

Abstract (Expand)

Diatoms are species-rich microalgae that often have a unique life cycle with vegetative cell size reduction followed by size restoration through sexual reproduction of two mating types (MT(+) and MT(-)). ...

Authors: K. G. Bondoc, C. Lembke, W. Vyverman, Georg Pohnert

Date Published: 5th Jun 2016

Journal: Microb Ecol

Abstract (Expand)

Almost all life forms depend on iron as an essential micronutrient that is needed for electron transport and metabolic processes. Siderophores are low-molecular-weight iron chelators that safeguard the ...

Authors: Colette Kurth, H. Kage, Markus Nett

Date Published: 6th Aug 2016

Journal: Org Biomol Chem

Abstract (Expand)

The targeted drug delivery to the central nervous system represents one of the major challenges in pharmaceutical formulations since it is strictly limited through the highly selective blood-brain ...

Authors: Christoph Englert, A. K. Trutzschler, M. Raasch, T. Bus, P. Borchers, A. S. Mosig, A. Traeger, Ulrich S. Schubert

Date Published: 19th Oct 2016

Journal: J Control Release

Abstract (Expand)

Microbes that live inside insects play critical roles in host nutrition, physiology, and behavior. Although Lepidoptera (butterflies and moths) are one of the most diverse insect taxa, their microbial ...

Authors: B. Chen, Beng Soon Teh, C. Sun, S. Hu, X. Lu, Wilhelm Boland, Y. Shao

Date Published: 9th Jul 2016

Journal: Sci Rep

Abstract (Expand)

The alkaline gut of Lepidopterans plays a crucial role in shaping communities of bacteria. Enterococcus mundtii has emerged as one of the predominant gut microorganisms in the gastrointestinal tract ...

Authors: Beng Soon Teh, J. Apel, Y. Shao, Wilhelm Boland

Date Published: 6th Jul 2016

Journal: Front Microbiol

Abstract (Expand)

Basidiomycete fungi are characterized ecologically for their vital functional role in ecosystem carbon recycling and chemically for their capacity to produce a diverse array of small molecules. ...

Authors: None

Date Published: 5th Oct 2016

Journal: Environ Microbiol

Abstract (Expand)

Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms. ...

Authors: Tina Netzker, J. Fischer, J. Weber, D. J. Mattern, C. C. Konig, V. Valiante, Volker Schroeckh, Axel A. Brakhage

Date Published: 20th Apr 2015

Journal: Front Microbiol

Abstract (Expand)

Streptomyces iranensis HM 35 is an alternative rapamycin producer to Streptomyces rapamycinicus Targeted genetic modification of rapamycin-producing actinomycetes is a powerful tool for the directed ...

Authors: Tina Netzker, Volker Schroeckh, M. A. Gregory, M. Flak, M. K. Krespach, P. F. Leadlay, Axel A. Brakhage

Date Published: 15th Jun 2016

Journal: Appl Environ Microbiol

Abstract:

Not specified

Authors: None

Date Published: 2nd Sep 2014

Journal: Proc Natl Acad Sci U S A

Abstract (Expand)

MOTIVATION: Secondary metabolites (SM) are structurally diverse natural products of high pharmaceutical importance. Genes involved in their biosynthesis are often organized in clusters, i.e., are ...

Authors: T. Wolf, V. Shelest, N. Nath, Ekaterina Shelest

Date Published: 9th Dec 2015

Journal: Bioinformatics

Abstract (Expand)

Photoreactive siderophores have a major impact on the growth of planktonic organisms. To date, these molecules have mainly been reported from marine bacteria, although evidence is now accumulating that ...

Authors: Colette Kurth, S. Schieferdecker, K. Athanasopoulou, I. Seccareccia, Markus Nett

Date Published: 29th Mar 2016

Journal: J Nat Prod

Abstract (Expand)

5-Lipoxygenase (5-LO) catalyzes the initial steps in the biosynthesis of proinflammatory leukotrienes. Upon cell activation, 5-LO translocates to the nuclear membrane where arachidonic acid is transferred ...

Authors: J. Gerstmeier, C. Weinigel, S. Rummler, O. Radmark, Oliver Werz, U. Garscha

Date Published: 22nd Sep 2015

Journal: FASEB J

Abstract (Expand)

Raman spectroscopy is a label-free method that measures quickly and contactlessly, providing detailed information from the sample, and has proved to be an ideal tool for medical and life science research. ...

Authors: U. Neugebauer, Petra Rösch, Jürgen Popp

Date Published: 6th Nov 2015

Journal: Int J Antimicrob Agents

Abstract (Expand)

Raman microspectroscopy has increased in popularity in the field of microbiology because it allows a spectral fingerprinting of bacterial pathogens at an unrivaled speed, which is important for the ...

Authors: S. Stockel, A. S. Stanca, J. Helbig, Petra Rösch, Jürgen Popp

Date Published: 21st Sep 2015

Journal: Anal Bioanal Chem

Abstract (Expand)

Leukotrienes (LTs) are proinflammatory lipid mediators formed from arachidonic acid in a 2-step reaction catalyzed by 5-lipoxygenase (5-LOX) requiring the formation of 5-HPETE (5(S)-hydroperoxyeicosatetraenoic ...

Authors: J. Gerstmeier, M. E. Newcomer, S. Dennhardt, E. Romp, J. Fischer, Oliver Werz, U. Garscha

Date Published: 5th Feb 2016

Journal: FASEB J

Abstract (Expand)

Humulus lupulus (hop plant) has long been used in traditional medicine as a sedative and antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic activity of the plant ...

Authors: M. Forino, Simona Pace, G. Chianese, L. Santagostini, Markus Werner, C. Weinigel, S. Rummler, G. Fico, Oliver Werz, O. Taglialatela-Scafati

Date Published: 27th Feb 2016

Journal: J Nat Prod

Abstract (Expand)

Leukotrienes (LTs) are lipid mediators derived from arachidonic acid (AA) involved in a number of autoimmune/inflammatory disorders including asthma, allergic rhinitis and cardiovascular diseases. ...

Authors: A. Rossi, Simona Pace, F. Tedesco, E. Pagano, G. Guerra, F. Troisi, Markus Werner, F. Roviezzo, J. K. Zjawiony, Oliver Werz, A. A. Izzo, R. Capasso

Date Published: 10th Feb 2016

Journal: Pharmacol Res

Abstract (Expand)

Pyoverdine is a substance which is excreted by fluorescent pseudomonads in order to scavenge iron from their environment. Due to specific receptors of the bacterial cell wall, the iron loaded pyoverdine ...

Authors: S. Pahlow, S. Stockel, S. Pollok, D. Cialla-May, Petra Rösch, K. Weber, Jürgen Popp

Date Published: 8th Jan 2016

Journal: Anal Chem

Abstract (Expand)

The siderophore myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). To clarify whether the iron-chelating properties of myxochelin A are responsible for this activity, several analogues ...

Authors: J. Korp, S. Konig, S. Schieferdecker, H. M. Dahse, G. M. Konig, Oliver Werz, Markus Nett

Date Published: 13th Oct 2015

Journal: Chembiochem

Abstract (Expand)

Axenic gametes of the marine green macroalga Ulva mutabilis Foyn (Ria Formosa, locus typicus) exhibit abnormal development into slow-growing callus-like colonies with aberrant cell walls. Under laboratory ...

Authors: J. Grueneberg, A. H. Engelen, R. Costa, Thomas Wichard

Date Published: 8th Jan 2016

Journal: PLoS One

Abstract (Expand)

Biological nitrogen fixation can be catalyzed by three isozymes of nitrogenase: Mo-nitrogenase, V-nitrogenase and Fe-nitrogenase. The activity of these isozymes strongly depends on their metal cofactors, ...

Authors: C. Jouogo Noumsi, N. Pourhassan, R. Darnajoux, Michael Deicke, Thomas Wichard, V. Burrus, J. P. Bellenger

Date Published: 10th Nov 2015

Journal: Environ Microbiol Rep

Abstract (Expand)

The basidiomycetous tree pathogen Armillaria mellea (honey mushroom) produces a large variety of structurally related antibiotically active and phytotoxic natural products, referred to as the melleolides. ...

Authors: J. Wick, D. Heine, G. Lackner, M. Misiek, James Tauber, H. Jagusch, Christian Hertweck, Dirk Hoffmeister

Date Published: 15th Dec 2015

Journal: Appl Environ Microbiol

Abstract (Expand)

BACKGROUND: Polyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants. Here, we have analyzed ...

Authors: Ekaterina Shelest, N. Heimerl, M. Fichtner, Sasso Severin

Date Published: 26th Nov 2015

Journal: BMC Genomics

Abstract (Expand)

Around 25% of vegetable food is lost worldwide because of infectious plant diseases, including microbe-induced decay of harvested crops. In wet seasons and under humid storage conditions, potato tubers ...

Authors: G. Shabuer, K. Ishida, S. J. Pidot, M. Roth, H. M. Dahse, Christian Hertweck

Date Published: 7th Nov 2015

Journal: Science

Abstract (Expand)

The exchange of chemical compounds is central to the interactions of microalgae with other microorganisms. Although foundational for many food webs, these interactions have been poorly studied compared ...

Authors: E. F. Hom, Prasad Aiyar, Daniel Schaeme, Maria Mittag, Sasso Severin

Date Published: 28th Oct 2015

Journal: Trends Plant Sci

Abstract (Expand)

The symbiotic fungus Paxillus involutus serves a critical role in maintaining forest ecosystems, which are carbon sinks of global importance. P. involutus produces involutin and other 2,5-diarylcyclopentenone ...

Authors: J. Braesel, S. Gotze, F. Shah, D. Heine, James Tauber, Christian Hertweck, A. Tunlid, P. Stallforth, Dirk Hoffmeister

Date Published: 27th Oct 2015

Journal: Chem Biol

Abstract (Expand)

Green Ulvophyte macroalgae represent attractive model systems for understanding growth, development, and evolution. They are untapped resources for food, fuel, and high-value compounds, but can also ...

Authors: E. F. Vesty, R. W. Kessler, Thomas Wichard, J. C. Coates

Date Published: 26th Jan 2015

Journal: Front Plant Sci

Abstract (Expand)

Green macroalgae, mostly represented by the Ulvophyceae, the main multicellular branch of the Chlorophyceae, constitute important primary producers of marine and brackish coastal ecosystems. Ulva or ...

Authors: Thomas Wichard, B. Charrier, F. Mineur, J. H. Bothwell, O. D. Clerck, J. C. Coates

Date Published: 19th Feb 2015

Journal: Front Plant Sci

Abstract (Expand)

Green macroalgae, such as Ulvales, lose their typical morphology completely when grown under axenic conditions or in the absence of the appropriate microbiome. As a result, slow growing aberrant ...

Authors: None

Date Published: 3rd Mar 2015

Journal: Front Plant Sci

Abstract (Expand)

Extracts of the predatory myxobacterium Pyxidicoccus fallax HKI 727 showed antiproliferative effects on leukemic K-562 cells. Bioactivity-guided fractionation led to the isolation of the bis-catechol ...

Authors: S. Schieferdecker, S. Konig, Andreas Koeberle, H. M. Dahse, Oliver Werz, Markus Nett

Date Published: 16th Feb 2015

Journal: J Nat Prod

Abstract (Expand)

The opportunistic pathogenic mold Aspergillus fumigatus is an increasing cause of morbidity and mortality in immunocompromised and in part immunocompetent patients. A. fumigatus can grow in multicellular ...

Authors: S. Bruns, M. Seidler, D. Albrecht, S. Salvenmoser, N. Remme, C. Hertweck, A. A. Brakhage, O. Kniemeyer, F. M. Muller

Date Published: 21st Jul 2010

Journal: Proteomics

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