Shuaibing Zhang

About Shuaibing Zhang:
No description specified

SEEK ID: https://data.chembiosys.de/people/98

Location:  Germany

ORCID: Not specified

Joined: 8th Dec 2018

Expertise: NMR, LC/MS, Analytical Chemistry, Chemistry

Tools: NMR, PCR, LC/MS, Chromatography

help Their tags

This person has not yet tagged anything.

Related items

Total ChemBioSys
No description specified

Public web page: Not specified

Max-Planck-Institut für Chemische Ökologie

Country:  Germany

City: Jena

Web page: Not specified

10 hidden items
Lipopeptide-mediated bacterial interaction enables cooperative predator defense
Total ChemBioSys

Abstract (Expand)

Bacteria are inherently social organisms whose actions should ideally be studied within an interactive ecological context. We show that the exchange and modification of natural products enables two … unrelated bacteria to defend themselves against a common predator. Amoebal predation is a major cause of death in soil bacteria and thus it exerts a trong selective pressure to evolve defensive strategies. A systematic analysis of binary combinations of coisolated bacteria revealed strains that were individually susceptible to predation but together killed their predator. This cooperative defense relies on a Pseudomonas species producing syringafactin, a lipopeptide, which induces the production of peptidases in a Paenibacillus strain. These peptidases then degrade the innocuous syringafactin into compounds, which kill the predator. A combination of bioprospecting, coculture experiments, genome modification, and transcriptomics unravel this novel natural product-based defense strategy.

Authors: Shuaibing Zhang, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, Pierre Stallforth

Date Published: 1st Feb 2021

Publication Type: Journal

Powered by
 (v.1.11.3)
About | ChemBioSys | Funding and Programmes | Credits
Copyright © 2008 - 2021 The University of Manchester and HITS gGmbH