Taking Different Roads: l-Tryptophan as the Origin of Psilocybe Natural Products.

Abstract:

Psychotropic fungi of the genus Psilocybe, colloquially referred to as "magic mushrooms", are best known for their l-tryptophan-derived major natural product, psilocybin. Yet, recent research has revealed a more diverse secondary metabolism that originates from this amino acid. In this minireview, the focus is laid on l-tryptophan and the various Psilocybe natural products and their metabolic routes are highlighted. Psilocybin and its congeners, the heterogeneous blue-colored psilocyl oligomers, alongside beta-carbolines and N,N-dimethyl-l-tryptophan, are presented as well as current knowledge on their biosynthesis is provided. The multidisciplinary character of natural product research is demonstrated, and pharmacological, medicinal, ecological, biochemical, and evolutionary aspects are included.

SEEK ID: https://data.chembiosys.de/publications/137

PubMed ID: 33237633

Projects: B05

Publication type: Journal

Journal: Chempluschem

Citation: Chempluschem. 2021 Jan;86(1):28-35. doi: 10.1002/cplu.202000581. Epub 2020 Nov 25.

Date Published: 26th Nov 2020

Registered Mode: by PubMed ID

Authors: C. Lenz, A. Sherwood, R. Kargbo, D. Hoffmeister

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Created: 10th May 2021 at 14:02

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