Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system.


Genome mining and chemical analyses revealed that rhizosphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a logbeta value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex.


PubMed ID: 30061716

Projects: B1

Publication type: Journal

Journal: Nat Chem Biol

Citation: Nat Chem Biol. 2018 Sep;14(9):841-843. doi: 10.1038/s41589-018-0101-9. Epub 2018 Jul 30.

Date Published: 1st Aug 2018

Registered Mode: by PubMed ID

Authors: R. Hermenau, K. Ishida, S. Gama, B. Hoffmann, M. Pfeifer-Leeg, W. Plass, J. F. Mohr, T. Wichard, H. P. Saluz, C. Hertweck

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Created: 26th Nov 2021 at 13:10

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