Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99.


Based on high-resolution tandem mass spectrometry (HR-MS(2)) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

SEEK ID: https://data.chembiosys.de/publications/119

PubMed ID: 32946237

Projects: A06

Publication type: Journal

Journal: J Nat Prod

Citation: J Nat Prod. 2020 Oct 23;83(10):3102-3110. doi: 10.1021/acs.jnatprod.0c00676. Epub 2020 Sep 18.

Date Published: 23rd Oct 2020

Registered Mode: by PubMed ID

Authors: S. Rak Lee, F. Schalk, J. W. Schwitalla, R. Benndorf, J. Vollmers, A. K. Kaster, Z. W. de Beer, M. Park, M. J. Ahn, W. H. Jung, C. Beemelmanns, K. H. Kim

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Created: 5th Feb 2021 at 10:51

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