Investigations
What is an Investigation?
Natural Products, Structure Elucidation, Burkholderia, gladioli, Lagria, villosa, insect symbiont, protective symbiosis
Submitter: Kirstin Scherlach
Studies: An antifungal polyketide associated with horizontally acquired genes sup..., Antibiotic-producing symbionts dynamically transition between plant path..., Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen
Assays: Structure elucidation of lagriamide, Structure elucidation of lagriene, Structure elucidation of secondary metabolites from Escovopsis sp., Structure elucidation of sinapigladioside
A combination of Raman microspectroscopy, genome mining and mutational analysis, we discovered a polyyne toxin, protegencin, which is secreted by P. protegens, penetrates the algal cells, and destroys the carotenoids of their primitive visual system, the eyespot.
Burkholderia gladioli, cocovenenans, food-poisoning, tempeh, bonkrekic, acid, chemical, Natural Products
Natural Products, Structure Elucidation, Burkholderia, gladioli, Lagria, villosa, insect symbiont, protective symbiosis
Pseudomonas tolaasii is the causative effect of bacterial brown blotch disease in the common button mushroom Agaricus bisporus. Some strains of the genus Mycetocola were identified that can suppress the disease symptoms when inoculated to the mushroom cap prior to infection with P. tolaasii. We investigate the molecular basis of the disease suppressive effect of different Mycetocola species.
Natural Products, Endosymbionts, Rhizopus microsporus, Mycetohabitans, Structure Elucidation, Symbiosis
We investigated the role of chemical signaling between two co-occurring bacteria that each make up more than 10% of the community in iron-rich lakes aggregates (iron snow) by comparative metagenomics and propose a model that shows rapid iron snow formation and ultimately energy transfer from the photic zone to deeper water layers are controlled via a chemically mediated interplay.
We study the transcriptional landscape of C. glabrata and identify differentially expressed genes between pH4 and ph8 as well as between nitrosative stress (GSNO) treatment and controll. Candida glabrata was grown in standard nutrient-rich medium, ph4, ph8 and in GSNO conditions. Paired-end and strand-specific RNA-Seq was performed on three biological replicates after PolyA filtering. A fourth replicate without filtering was sequenced single-end and not strand-specific.
