Structure elucidation of lagriamide

No description specified

SEEK ID: https://data.chembiosys.de/assays/30

Class: Experimental assay

Projects: B1

Investigation: Chemical Ecology of Insect Symbionts

Study: An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

Assay type: Experimental Assay Type

Technology type: Technology Type

Organisms: No organisms

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Kirstin Scherlach

Submitter

Kirstin Scherlach

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Created: 30th Nov 2021 at 10:54

Last updated: 30th Nov 2021 at 10:55

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Kirstin Scherlach

Projects: B1

Institutions: HKI

Cryptic Mediators at the Bacterial-Fungal Interface: Mushroom Soft Rot Diseases as Infection Model

Public web page: Not specified

Organisms: Streptomyces rapamycinicus, Candida albicans, Aspergillus nidulans, Aspergillus fumigatus, Janthinobacterium agaricidamnosum, Mycetocola lacteus, Mycetocola tolaasinivorans, Pseudomonas tolaasii, Burkholderia sp. strain B4, Burkholderia sp. strain B7, Burkholderia sp. strain B8, Mycetohabitans endofungorum, Mycetohabitans rhizoxinica, Burkholderia gladioli

Chemical Ecology of Insect Symbionts

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Kirstin Scherlach

Natural Products, Structure Elucidation, Burkholderia, gladioli, Lagria, villosa, insect symbiont, protective symbiosis

Submitter: Kirstin Scherlach

Studies: An antifungal polyketide associated with horizontally acquired genes sup..., Antibiotic-producing symbionts dynamically transition between plant path..., Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen

Assays: Structure elucidation of lagriamide, Structure elucidation of lagriene, Structure elucidation of secondary metabolites from Escovopsis sp., Structure elucidation of sinapigladioside

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Created: 30th Nov 2021 at 10:14

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

All creators

Kirstin Scherlach

No description specified

Submitter: Kirstin Scherlach

Investigation: Chemical Ecology of Insect Symbionts

Assays: Structure elucidation of lagriamide

Snapshots: No snapshots

Created: 30th Nov 2021 at 10:53

NMR data lagriamide

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Kirstin Scherlach

No description specified

Creator: Kirstin Scherlach

Submitter: Kirstin Scherlach

Relationship type: Not specified

Investigations: Chemical Ecology of Insect Symbionts

Studies: An antifungal polyketide associated with horizo...

Assays: Structure elucidation of lagriamide

Created: 30th Nov 2021 at 10:55

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles.

All authors

Kirstin Scherlach

Christian Hertweck

Abstract (Expand)

Microbial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance of chemical mediators remains unclear for most … systems. Lagria beetles live in symbiosis with multiple strains of Burkholderia bacteria that protect their offspring against pathogens. Here, we describe the antifungal polyketide lagriamide, and provide evidence supporting that it is produced by an uncultured symbiont, Burkholderia gladioli Lv-StB, which is dominant in field-collected Lagria villosa. Interestingly, lagriamide is structurally similar to bistramides, defensive compounds found in marine tunicates. We identify a gene cluster that is probably involved in lagriamide biosynthesis, provide evidence for horizontal acquisition of these genes, and show that the naturally occurring symbiont strains on the egg are protective in the soil environment. Our findings highlight the potential of microbial symbionts and horizontal gene transfer as influential sources of ecological innovation.

Authors: L. V. Florez, K. Scherlach, I. J. Miller, A. Rodrigues, J. C. Kwan, C. Hertweck, M. Kaltenpoth

Date Published: 26th Jun 2018

Publication Type: Journal

PubMed ID: 29946103

Citation: Nat Commun. 2018 Jun 26;9(1):2478. doi: 10.1038/s41467-018-04955-6.

Created: 24th Nov 2021 at 10:31