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Programme: Collaborative Research Center 1127: Chemical Mediators in Complex Biosystems - ChemBioSys2
Author: Michael Pröhl2
d-Fructose-Decorated Poly(ethylene imine) for Human Breast Cancer Cell Targeting

Abstract (Expand)

The high affinity of GLUT5 transporter for d-fructose in breast cancer cells has been discussed intensely. In this contribution, high molar mass linear poly(ethylene imine) (LPEI) is functionalized … with d-fructose moieties to combine the selectivity for the GLUT5 transporter with the delivery potential of PEI for genetic material. The four-step synthesis of a thiol-group bearing d-fructose enables the decoration of a cationic polymer backbone with d-fructose via thiol-ene photoaddition. The functionalization of LPEI is confirmed by 2D NMR techniques, elemental analysis, and size exclusion chromatography. Importantly, a d-fructose decoration of 16% renders the polymers water-soluble and eliminates the cytotoxicity of PEI in noncancer L929 cells, accompanied by a reduced unspecific cellular uptake of the genetic material. In contrast, the cytotoxicity as well as the cell specific uptake is increased for triple negative MDA-MB-231 breast cancer cells. Therefore, the introduction of d-fructose shows superior potential for cell targeting, which can be assumed to be GLUT5 dependent.

Authors: C. Englert, M. Prohl, J. A. Czaplewska, C. Fritzsche, E. Preussger, U. S. Schubert, A. Traeger, M. Gottschaldt

Date Published: 4th Apr 2017

Publication Type: Not specified

Photocontrolled Release of Chemicals from Nano- and Microparticle Containers.

Abstract (Expand)

A benzoin-derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker … unit was performed to enable the defined encapsulation of diverse organic compounds in the polymeric structures and allow for a well-controllable polymer cleavage process. Selective tracking of the release kinetics of encapsulated model compounds from the polymeric nano- and microparticle containers was performed by confocal laser scanning microscopy in a proof-of-principle study. The physicochemical properties of the incorporated and released model compounds ranged from fully hydrophilic to fully hydrophobic. The demonstrated biocompatibility of the utilized polyesters and degradation products enables their use in advanced applications, for example, for the smart packaging of UV-sensitive pharmaceuticals, nutritional components, or even in the area of spatially selective self-healing processes.

Authors: C. Englert, I. Nischang, C. Bader, P. Borchers, J. Alex, M. Prohl, M. Hentschel, M. Hartlieb, A. Traeger, G. Pohnert, S. Schubert, M. Gottschaldt, U. S. Schubert

Date Published: No date defined

Publication Type: Not specified

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