Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars.


Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.


PubMed ID: 27341414

Projects: Associated project 2, B1

Journal: Org Lett

Citation: Org Lett. 2016 Jul 15;18(14):3338-41. doi: 10.1021/acs.orglett.6b01437. Epub 2016 Jun 24.

Date Published: 25th Jun 2016

Authors: H. Guo, Nina Kreuzenbeck, S. Otani, M. Garcia-Altares, H. M. Dahse, C. Weigel, D. K. Aanen, Christian Hertweck, M. Poulsen, Christine Beemelmanns

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Created: 23rd Nov 2017 at 09:18

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