Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
PubMed ID: 27341414
Journal: Org Lett
Citation: Org Lett. 2016 Jul 15;18(14):3338-41. doi: 10.1021/acs.orglett.6b01437. Epub 2016 Jun 24.
Date Published: 25th Jun 2016
Created: 23rd Nov 2017 at 09:18